Ovine Fetal Leucine Kinetics During Graded infusion of rhIGF-1 • 401
نویسندگان
چکیده
منابع مشابه
Ovine fetal leucine kinetics and protein metabolism during decreased oxygen availability.
The fetus depends on an uninterrupted supply of oxygen to provide energy, not only for basal metabolism but also for the metabolic costs of growth. By curtailing the metabolically expensive processes of protein turnover, the fetus could conserve energy when oxygen availability is limited. Therefore, this investigation was performed to find whether protein synthesis and breakdown are diminished ...
متن کاملGlucose and amino acid kinetic response to graded infusion of rhIGF-I in the late gestation ovine fetus.
Insulin-like growth factor I (IGF-I) has anabolic effects and is thought to be important in fetal development. The present study was designed to determine the dose response of recombinant human (rh) IGF-I on ovine fetal glucose and amino acid kinetics. Chronically catheterized fetal lambs were studied at 122-127 days gestation. The kinetics of leucine, phenylalanine, and glucose were measured b...
متن کاملEffect of rhIGF-I infusion on whole fetal and fetal skeletal muscle protein metabolism in sheep.
Insulin-like growth factor I (IGF-I) has been shown to have significant anabolic effects in the regulation of fetal protein metabolism. To investigate the tissue-specific effects of IGF-I on fetal skeletal muscle metabolism, we infused recombinant human (rh) IGF-I directly into the hindlimb of nine chronically catheterized, late-gestation fetal sheep. Substrate balance and amino acid kinetics w...
متن کاملEffects of insulin on ovine fetal leucine kinetics and protein metabolism.
Fetuses of eight pregnant ewes (114-117 d of gestation) were used to study whether fetal insulin concentration affects fetal protein accretion and, if so, whether such changes are caused by effects on protein synthesis or protein breakdown. Fetal leucine kinetics were measured by infusion of [1-14C]leucine during each of three protocols: (I) low vs. normal insulin concentration; (II) low vs. hi...
متن کاملInduction of glutamate dehydrogenase in the ovine fetal liver by dexamethasone infusion during late gestation.
Glucocorticoids near term are known to upregulate many important enzyme systems prior to birth. Glutamate dehydrogenase (GDH) is a mitochondrial enzyme that catalyzes both the reversible conversion of ammonium nitrogen into organic nitrogen (glutamate production) and the oxidative deamination of glutamate resulting in 2-oxoglutarate. The activity of this enzyme is considered to be of major impo...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1997
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199704001-00421